Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

Josef Dankiewicz, Tobias Cronberg, Gisela Lilja et el published a trial of normothermia vs hypothermia in out of hospital cardiac arrest in NEJM. BACKGROUND Targeted temperature management (TTM, therapeutic hypothermia) after cardiac arrest first came to use in clinical setting since the publication of two landmark articles in 2002(1,2). Earlier it was noted that persons … Read more

ECMO in refractory out of hospital VFib cardiac arrest

Yannopoulos D, Bartos J, Raveendran G, Walser E, et al published a trial in the Lancet   about therapy in patients with out of hospital  refractory ventricular fibrillation cardiac arrest.  WHAT Phase 2, single-center, open-label, pragmatic, randomized clinical trial.   WHERE University of Minnesota Medical Center (MN, USA) PATIENTS Adult patients (aged 18-75) with out of hospital … Read more

Covid 19 : Current Knowledge and gaps

Since the beginning of the pandemic with covid-19, We have learned a lot  regarding prevention and treatment. However,  the knowledge Gap exists. Recent JAMA  editorial summarized this for severe covid-19.   PREVENTION Social distancing, frequent hand washing and mask wearing by the general public reduces the transmission  of covid 19. Contact tracing and isolation are … Read more

Update in cardiac resuscitation : New CPR Guidelines

Ashish Panchel, Jason Bartos, Jose Cabanas et el published uptdated guidelines for cardiac resuscitation in Circulation. Salient features are summarized in this picture. Now a days the guidelines are updated on a continuous basis but these are the salient changes summarized in a table form. Most updated treatment recommendations for cardiac arrest resuscitation   FOR … Read more

Tranexamic Acid fails to work in Gastrointestinal hemorrhage

Ian Roberts, Haleema Shakur-Still , Adefemi Afolabi, Christopher Hawkey et el (HALT-IT trial investigators) published a trial in Lancet  comparing tranexamic acid to placebo in gastrointestinal hemorrhage. Background Tranexamic acid(TXA) is known to prevent the  fibrinolysis.  Early use of TXA reduces surgical bleeding and death related to bleeding from traumatic injury and has reduced the … Read more

No difference in mortality with Balanced Solution vs 0.9% Saline Solution in Critically Ill PatientsRead more
+