Infectious disease
Surviving Sepsis Guidelines 2026 : What’s New
Domain 2021 Guidelines 2026 Guidelines (Update) What This Means Clinically Overall approach Protocolized bundles (Hour-1 bundle emphasized) More individualized, patient-centered care; less rigid bundles Move away from “checklist medicine” → nuanced decisions Performance improvement Recommended but less emphasized Strong recommendation for sepsis performance/QI programs Hospitals expected to actively track & improve sepsis care Antibiotics timing … Read more
Continuous infusion of beta-lactam antibiotics improves mortality in sepsis
Reference https://jamanetwork.com/journals/jama/fullarticle/2819971
ATS Guidelines on ARDS
American thoracic society published guidelines on ARDS, Here is the summary
Steroids in severe community acquired pneumonia
Pierre-François Dequin, Ferhat Meziani et el published a trial in NEJM about use of steroids in severe community acquired pneumonia. Results are summarized here-
Restrictive versus Liberal fluids in Septic shock
Tine S. Meyhoff, Peter B. Hjortrup et el(Classic Trial Group-Conservative versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care) published study in NEJM comparing restrictive vs standard fluid therapy in septic shock. WHAT This was an international, stratified, parallel-group, open-label, randomized clinical trial in 31 ICUs in Denmark, Norway, Sweden, Switzerland, Italy, … Read more
Outpatient COVID treatment
This may reduce the need for hospitalization. Source NIH