Continuous infusion of beta-lactam antibiotics improves mortality in sepsis
Reference https://jamanetwork.com/journals/jama/fullarticle/2819971
pharmacology
ATS Guidelines on ARDS
American thoracic society published guidelines on ARDS, Here is the summary
Steroids in severe community acquired pneumonia
Pierre-François Dequin, Ferhat Meziani et el published a trial in NEJM about use of steroids in severe community acquired pneumonia. Results are summarized here-
Update in cardiac resuscitation
Following table summarizes latest in cardiac resuscitation
Extremity Threat and Amputation after Vasopressor-Dependent Sepsis
Katherine M Reitz , Jason Kennedy , Caroline Rieser et el published a retrospective cohort study about epidemiology of extremity threat in case of vasopressor dependent sepsis.
Outpatient COVID treatment
This may reduce the need for hospitalization. Source NIH
Covid 19 : Current Knowledge and gaps
Since the beginning of the pandemic with covid-19, We have learned a lot regarding prevention and treatment. However, the knowledge Gap exists. Recent JAMA editorial summarized this for severe covid-19. PREVENTION Social distancing, frequent hand washing and mask wearing by the general public reduces the transmission of covid 19. Contact tracing and isolation are … Read more
Tranexamic Acid fails to work in Gastrointestinal hemorrhage
Ian Roberts, Haleema Shakur-Still , Adefemi Afolabi, Christopher Hawkey et el (HALT-IT trial investigators) published a trial in Lancet comparing tranexamic acid to placebo in gastrointestinal hemorrhage. Background Tranexamic acid(TXA) is known to prevent the fibrinolysis. Early use of TXA reduces surgical bleeding and death related to bleeding from traumatic injury and has reduced the … Read more
IV Thiamine fails again in Septic Shock
Miyamoto, Yoshihisa, Aso, Shotaro et el published results of retrospective Cohort study in critical care medicine. With ongoing covid 19, all possible medications are being tried for which they were not originally intended. Similarly several medications have been tried in septic shock but failed. Recent trial was discussed here. Given there was a lot of … Read more