Paul Marik et el published a “retrospective before after ” study in Chest, Dec, 2016 about use of combination of parenteral Vit C, Thiamine and Hydrocortisone in sepsis and reported a mortality of 8.5% in treatment group compared with 40.4% in control group(p =<0.001).
Results are astonishing if you believe in the study.
There are several problems with the study.
- Retrospective
- Before after
- Why use combination of three ? Does combination work better than individual meds ? Is there a synergistic effect ?
- Single center
- Less number of patients
- Potential bias by investigators
Bottom Line
We need multi center randomized placebo controlled trial to really assess the claim.