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Landmark Articles

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In this space, we will post summaries of landmark articles from field of critical care.

Brief News

4/1/2025

Severe Sepsis and Septic Shock Management Bundle (SEP-1) implementation does not work.

2/20/2025

Inhaled sedation with Sevoflurane associated with worse outcome in ARDS.

1/12/2025

Thymosin α1 not effective in sepsis.

12/12/2024

No difference in outcomes with IV or IO in out of hospital cardiac arrest.

10/2/2024

Liberal blood transfusion may improve neurological outcome in acute brain injury patients.

9/25/2024

Early mechanical ventilation(Day 1) in sepsis may improve outcome.

9/10/2024

Risk of atrial fibrillation after CABG same for low(3.6) vs high(4.5) potassium level.

9/1/2024

Intubation during transport leads to hemodynamic collapse.

8/20/2024

Moderate IV Fluid Resuscitation (4 litres) Is Associated With Decreased Sepsis Mortality.

7/15/2024

Pantoprazole reduces GI bleeding in intubated patients without improving mortality.

6/15/2024

Intravenous Amino Acids prevent kidney injury in cardiac surgery patients.

6/11/2024

Noninvasive Ventilation before intubation prevents hypoxia in emergent intubation.

5/19/2024

Video laryngoscopy better, in operating room as well.

4/19/2024

Hydrocortisone plus fludrocortisone improve mortality in CAP with Septic Shock.

3/20/2024

No difference in mortality between high(PaO2 90) vs low(PaO2 60) in intubated Covid patients.

3/1/2024

Probabilities of survival rapidly declines over time during CPR, less than 1% at 39 minutes.

2/1/2024

Haloperidol improves mortality in patients with delirium admitted to ICU.

1/2/2024

Etomidate use for endotracheal intubation in critically ill patients increases mortality.

12/23/2023

Daily toothbrushing reduces pneumonia and improves mortality in ICU.

12/11/2023

Prophylactic Minocycline may reduce ICU delirium.

12/3/2023

Prone positioning during ECMO for ARDS does not help.

11/26/2023

Small-Volume Blood Collection Tubes Reduce Transfusions in Intensive Care.

11/19/2023

Resuscitative endovascular balloon occlusion of the aorta (REBOA) does not improve mortality in trauma patients with exsanguinating hemorrhage.

11/18/2023

Early and empirical high-dose cryoprecipitate in trauma does not improve survival.

11/01/2023

Inhaled Amikacin reduces the incidence of Ventilator-Associated Pneumonia.

10/24/2023

Convalescent Plasma reduces mortality by 10% in Covid-19 on Mechanically Ventilation.

10/21/2023

Hydrocortisone outperforms(mortality benefit) all other steroids for community acquired pneumonia.

10/15/2023

No difference between Cefepime and Pip-Tazo in terms of acute kidney injury, need for renal replacement therapy, or death in sepsis.

10/14/2023

Betablockers harmful in septic shock treated with norepinephrine.

10/1/2023

PEEP of 10 ideal for ARDS patients on VV ECMO.

9/19/2023

Propafanone as good as Amiodarone for AFib in septic shock.

9/1/2023

Obese patients who need ECMO have better outcome than patients with normal BMI.

8/20/2023

Surgical rib fixation does not improve QOL in severe chest injury.

7/2/2023

Procalcitonin at admission not reliable for capturing bacteremia in sepsis.

6/28/2023

Catheter-directed thrombolysis compared with systemic thrombolysis and anticoagulation improves survival in in patients with intermediate- or high-risk pulmonary embolism.

6/12/2023

Continuous infusion of meropenem does not improve outcome in sepsis.

6/5/2023

Prehospital administration of tranexamic acid in severe trauma does not improve outcome.

6/1/2023

No difference between anakinra plus standard care vs standard care alone for reducing mortality risk or need for mechanical ventilation among patients hospitalized with severe COVID-19 pneumonia and hyperinflammation.

5/20/2023

Mannitol and Hypertonic Saline equally effective in TBI.

5/17/2023

No difference between higher dose methylprednisone and standard dexamethasone in COVID 19.

5/15/2023

Secondary bacterial pneumonia, not cytokine storm caused deaths in COVID 19.

4/12/2023

BCG vaccination doesn’t prevent COVID.

3/31/2023

High dose DVT prophylaxis better than standard dose in COVID hypoxic respiratory failure.

3/20/2023

Fludrocortisone added to hydrocortisone was associated with increased hospital survival, shorter length of stay, and decreased shock duration in septic shock.

2/28/2023

Condom catheters can be deadly.

Recent posts

PA catheter improves mortality in cardiac surgery patients March 3, 2025
Early versus Late Norepinephrine in Septic Shock December 2, 2024
Management of non malignant central airway obstruction November 8, 2024
Continuous infusion of beta-lactam antibiotics improves mortality in sepsis June 17, 2024
ATS Guidelines on ARDS April 30, 2024

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